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Advanced BCC

Among the 3.6 million people diagnosed with basal cell carcinoma (BCC) annually, most cases are easily treated. However, some cases can become advanced and, in rare instances, life-threatening.1
While most BCCs are detected and treated early, a small number progress to an advanced stage. These tumors can penetrate deeply into the skin and nearby tissues (locally advanced) or spread to other parts of the body (metastatic). Advanced BCCs can cause significant tissue damage, affecting muscles, bones, and nerves.1

Unlike early-stage BCC, advanced BCC may not be completely removed with surgery alone. Although surgery is the most common method for treating BCC, treatment for advanced BCC may involve surgery, radiation, or targeted therapy or immunotherapy. If surgery is not an option or the cancer cannot be fully removed, radiation therapy may be considered. If the cancer returns in nearby lymph nodes or other parts of the body, systemic treatments may be necessary.2,3

Early detection is crucial. Delaying a dermatologist visit can allow BCC to grow and become advanced. Regular skin checks and prompt treatment are essential to prevent complications. Advanced BCC can result from incomplete initial treatments, recurrent tumors, or neglect. Fear of diagnosis, treatment, or costs can lead to delays in seeking medical help, allowing the cancer to progress.1

References

  1. Skin Cancer Foundation. Sun & Skin News. When a Common Skin Cancer Advances. June 7, 2021. (https://www.skincancer.org/blog/when-a-common-skin-cancer-advances/).
  2. American Cancer Society. Treating Basal Cell Carcinoma. Last revised October 31, 2023. (https://www.cancer.org/cancer/types/basal-and-squamous-cell-skin-cancer/treating/basal-cell-carcinoma.html).
  3. National Comprehensive Cancer Network®. NCCN Guidelines for Patients: Basal Cell Skin Cancer. Version 2026. (https://www.nccn.org/patients/guidelines/content/PDF/basal-cell-patient-guideline.pdf)
All URLs accessed April 3, 2026
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